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Brand: Advantage Multi (Advocate)
Uses: Prevents heartworms and treats fleas, intestinal worms, ear mites, demodicosis, sarcoptic mange and chewing lice.
Doses: 1 Doses = 1 Month

Advantage Multi (Advocate) for Dogs

4.8/5 (181 Reviews)
In Stock, Price Starting From: $34.91

Advantage Multi (Advocate) Small Dogs 3-9 lbs (Green)

Pack Size
Sale Price
3 Doses
6 Doses
12 Doses

Advantage Multi (Advocate) Medium Dogs 9.1-20 lbs (Aqua)

Pack Size
Sale Price
3 Doses
6 Doses
12 Doses

Advantage Multi (Advocate) Large Dogs 20.1-55 lbs (Red)

Pack Size
Sale Price
3 Doses
6 Doses
12 Doses

Advantage Multi (Advocate) Extra Large Dogs 55.1-88 lbs (Blue)

Pack Size
Sale Price
3 Doses
6 Doses
12 Doses
  • Description
  • Key Benefits
  • Directions
  • Safety
  • More Info
  • FAQ

Advantage Multi for Dogs - Dog Heartworm Control

Advantage Multi for dogs is a broad-spectrum treatment for a wide range of parasites including fleas, heartworms, intestinal worms, ear mites, demodicosis, sarcoptic mange and chewing lice. It is a monthly topical solution that kills around 98-100% fleas within 12 hours. It also reduces Flea Allergy Dermatitis (FAD) and is an ideal treatment for various internal and external parasites.

How does it work?

Manufactured by Bayer, Advantage Multi is a highly potent broad spectrum anthelmintic for destroying fleas, heartworms, roundworm, hookworm, whipworm, ear mites, sarcoptic mange and biting lice. The once-a-month spot on application provides all round protection to all breeds of puppies and dogs.

Imidacloprid and Moxidectin are the active ingredients that attack neurotransmitters of the parasites. This paralyses the pests and kills them eventually. It treats canines for heartworm infections as well.

Key Benefits
  • Easy-to-apply topical formula
  • Broad-spectrum treatment to protect against multiple parasites
  • Kills adult fleas and eliminates flea larvae
  • Kills more than 95% fleas within 12 hours
  • Effectively prevents heartworm disease
  • Treats and controls hookworms, roundworms, and whipworms
  • Treats sarcoptic mange

Step1: Let the pet stand in a comfortable position. Create a bare skin spot between the shoulder blades by parting the fur.

Step2: Put the tip of the open pipette on the skin spot and press out the content until the pipette is empty.

Step3: For larger dogs, apply at 3-4 spots. Start from the spot between the shoulder blades and move across the backbone.

The application site must be completely dry. Pet should not lick or groom the site. Consult vet before treating pregnant and nursing dogs.

Dog Size Dog Weight Dose Per Month Dose Volume (mL) Imidacloprid (mg) Moxidectin (mg)
Small Dogs 3-9 lbs One 0.4 40 10
Medium Dogs 9.1-20 lbs One 1.0 100 25
Large Dogs 20.1 – 55 lbs One 2.5 250 62.5
Extra Large Dogs 55.1 – 88 lbs One 4.0 400 100
For over 88lbs dogs, use appropriate combination of Advantage Multi doses.
  • Do not administer Advantage Multi to puppies younger than 7 weeks of age.
  • Do not give to pets allergic to any of the ingredients.
  • Children and other pets should not touch or groom the treated pet until the application site is dry.
  • Do not let the pet lick the application site.
  • While applying, make sure you keep the pipette away from the pet’s eyes and face.
  • Wear gloves while treating the pet. After the treatment, wash hands and exposed skin with soap and lots of water.
  • Consult a vet before treating sick and weak pets.
  • Ask a vet before clubbing Advantage Multi with any other antiparasitic treatment.


  • There are no known condraindications of Advantage Multi (Advocate) on dogs.

Warning:Dogs of some breeds like collies including border collies are sensitive to moxidectin. They can suffer more or less serious adverse effects if treated at dose rates slightly higher than the recommended ones. Consequently, dosing must be as accurate as possible.

More Info
Target species Dogs
Treatment Type Internal and External Parasite Protection
Product Form Liquid
Effective Against Fleas, Heartworms, Roundworms, Hookworms, Whipworms, Sarcoptic Mange
Dosing Frequency Monthly
Mode of Administration Topical
Active Ingredients Imidacloprid, Moxidectin

What Does Advantage Multi For Dogs Treat?

Advantage Multi (Advocate) prevents heartworm infections and treats heartworm larvae, kills fleas, and treats intestinal worms including roundworms, hookworms, and whipworms. It also has the efficacy to treat sarcoptic mange.


How does Advantage Multi work to kill fleas?

Advantage Multi (Advocate) is applied to your dog’s skin. The solution, applied at a spot, spreads over your dog’s body to kill fleas through contact so they don’t have to bite your dog to die.


How Long Does Advantage Multi For Dogs Last?

Advantage Multi lasts for one full month. It should be given every month year-round for complete prevention against heartworm and fleas.


Is Advantage Multi Safe For Heartworm Positive Dogs?

It is not recommended to treat heartworm positive dogs with Advantage Multi without your vet’s consultation. It is advisable to check with the vet first for proper diagnosis and then continue the treatment, once the vet approves.


Can Advantage Multi For Dogs Be Used On Cats?

It is not recommended to use Advantage Multi for Dogs to be used in cats. It is advised only to buy products for cats that are specifically labeled for them. The products made for dogs can be very harmful and even toxic to cats.


Still Have Questions? – Please email us your queries at and we will be happy to help you.

Customer Review

Overall Rating


181 reviews

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Monthly protection against ticks and fleas PLUS heartworm disease in one easy package

May 30, 2024


Best to buy online

Top-rated supplements on the internet

May 18, 2024

Barb Pinkall


I like the fact it's applied to the coat of the dog. He won't chew or swallow the pill

May 17, 2024


Best one

Effective monthly treatment that addresses a wide range of pet preventive care aspects.

May 09, 2024


Must have

Effective monthly treatment that covers many areas of preventative care features for pets.

May 01, 2024

Have A Question?

question-arrow Do you have for dogs 88-110 lbs?

next-arrow The largest size we carry for Advocate is Advantage Multi (Advocate) Extra Large Dogs 55.1-88 lbs (Blue).

Jul 03, 2023
question-arrow Will you be carrying the largest size available of this the 88-110 lb ? Or would the 55-88 work on dogs over 88 pounds ?

next-arrow We will update it on our website if we start carrying Advantage Multi (Advocate) for more than 88 lbs of dogs. However, if your dog weighs more than 88 lbs, you can administer an appropriate combination of Advocate doses on your dogs after consulting with a vet.

Jun 27, 2023
question-arrow Will you ever carry the largest dog Advantage Multi?? Up to 110#?

next-arrow Currently, the largest pack size for Advantage Multi (Advocate) for Dogs we carry is for Extra Large Dogs weighing between 55.1-88 lbs (Blue Pack)

Nov 07, 2022
question-arrow My lab is 1 year old, 54 pounds, should I buy red or blue advantage.

next-arrow Advantage Multi (Advocate) Large Dogs 20.1-55 lbs (Red)

Apr 22, 2022
question-arrow Does it control ticks?

next-arrow No

Jan 11, 2022