Revolution vs. Sentinel Spectrum


Heartworms are a serious problem in pets that lead to fatal conditions causing vomiting, diarrhea, loss of appetite, listlessness and even death in extreme cases. Dogs affected by heartworms often suffer from cardiac blockages and respiratory problems. This deadly disease kills thousands of pets every year. However, with timely medication, the condition can be treated and prevented easily.

The most popular treatments available to prevent heartworms in pets come with additional protection too, which although makes it quite effective but very bewildering for pet owners to make a purchase decision. Hence, we thought to give our readers a proper comparison between Revolution and Sentinel Spectrum which are the two most renowned heartworm treatments for pets.

Comparison between Revolution and Sentinel Spectrum


  • Revolution contains selamectin which is a parasiticide and anthelmintic that kills all kinds of parasites and worms.

  • Sentinel spectrum contains milbemycin oxime, lufenuron, and praziquantel. Milbemycin oxime acts on the nervous system of the worms thus kill immature stages of heartworms and adult stages in the roundworm, hookworm, and whipworms. Lufenuron, on the other hand, is an insect growth regulator that disrupts flea lifecycle and thus stops them from laying eggs. Whereas praziquantel initiates muscle spams in tapeworms that ultimately kills them.

Treatment/ Protection

  • Revolution kills adult fleas, prevents them from laying eggs and also eliminates ticks and mites. It paralyzes the nervous system of heartworms, rendering them dead. However, it doesn’t treat intestinal worms.

  • Sentinel Spectrum is a potent wormer, hence, kills heartworms and other intestinal worms like roundworms, hookworms, whipworms as well as tapeworms. Note: It doesn’t kill adult fleas like a revolution. However, it does prevent flea egg development due to lufenuron present in the treatment.


  • Revolution is a topical treatment which must be applied to the specific spot over the shoulder blades of the pet.

  • Sentinel Spectrum, however, is an oral treatment which has to be administered directly or mixed with the pet meal to show the expected results.


  • Revolution is a topical treatment and is used both for cats and dogs. It is applied to the body of the pet thus cats can be easily treated with revolution, for they usually show aversion to tablets or chews.

  • Sentinel Spectrum is specifically meant for treating dogs (including pregnant and nursing ones). So make sure you don’t use it for cats.

Revolution for dogs

Buy Revolution Treatment at 20% Off

Buy Sentinel Spectrum


Both of the products are quite effective against heartworms but if you are searching for some additional protection against fleas as well then Revolution would be a better option to treat your furry companion. However, if you just want to prevent your pet from heartworm and intestinal worm infection, going with sentinel spectrum would be the best decision. So, choose wisely and do make sure to check the pack insert before administration of any drug.

View All Heartworm Preventions

Hope it was informational! For more such updates click here (An Introduction To Heartworm Disease in Pets)