Comparison Between Simparica Trio and Heartgard Plus for Dogs

Pet parents are well-worn with the havoc of parasites in their pet’s life. It seems like there’s no end when they pop up from nowhere. However, the pet care industry has emerged with a plethora of treatments to win over these pesky creatures. Among this multitude of options, two such wonderful products in the market are Simparica Trio and Heartgard Plus. In this blog, we have compared them to help you pick the best one for your pet.


Simparica Trio for Dogs

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Simparica Trio is an upgraded form of the renowned Simparica chewable oral treatment. This Zoetis manufactured product is a powerful and potent chewable that works as a multi-spectrum treatment to protect dogs from heavy flea and tick infestations. Moreover, Simparica Trio also controls roundworms and adult hookworms. The chews are indicated for the prevention of heartworm too. 

Read More: 

Simparica Trio for Dogs: Five Problems One Solution 


Heartgard Plus for Dogs

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Heartgard Plus for dogs is a vet-recommended heartworm preventive. This popular monthly treatment effectively controls heartworm infection and provides total protection against heartworm disease in dogs. These palatable chews also eliminate hookworm and roundworm from the dog’s system and safeguards dogs from harmful heartworm disease and intestinal worms.


Read More:

Heartgard Plus: A Must-Have Treatment For Dogs Heartworm Prevention


Here is a short video that will help you understand the difference between Heartgard Plus and Simparica quickly!



Comparison Chart for Heartgard Plus and Simparica Trio:

Heartgard Plus Vs Simparic Trio


Few things to Consider

Let’s start with the various similarities that exist between these two products. One of the most apparent parallels is that both products protect dogs from heartworms, roundworms, and hookworms. They’re both given once a month and come in the form of a chewable, beef-flavored tablet. They’re also both safe to use with pups. Heartgard Plus can be given to puppies as soon as 6 weeks old. Simparica Trio can be given to puppies as young as 2.8 pounds and 8 weeks old.

The active ingredients in Heartgard Plus include Ivermectin and Pyrantel Pamoate. This product is safe to use on pregnant or breeding dogs. Simparica Trio has three active ingredients: moxidectin, pyrantel, and saroloner. These components work together to protect dogs against the parasites mentioned above, as well as to kill fleas in all phases of life: adult, larval, and egg. Ticks are also no longer a problem. Simparica Trio has not been proven to be safe for dogs that are pregnant, nursing, or breeding.


Simparica Trio and Heartgard Plus are two powerful products in the pet market that holds a similarity in treating intestinal worms and preventing heartworms in dogs. However, it is essential for pet parents to know that Simaprica Trio is an all-on-one monthly chewable that protect dogs against five types of ticks, fleas, roundworms, hookworms, and heartworms. Whereas Heartgard Plus can only treat hookworm and roundworms, and prevent heartworms. Therefore, if you are looking for a one-stop solution to combat all parasites then Simparica Trio is the right pick.

So, what are you waiting for? Both the potent products are available at CanadaVetExpress at discounted prices.