Comparison Between Simparica Trio and Heartgard Plus for Dogs

Pet-parents are well-worn with how the parasites have been havoc in their pets’ life. It seems like there’s no end when every time they pop up from nowhere. Well, the pet industry indeed has emerged with a plethora of flea and ticks treatments along with other parasitic treatments. However, to make it easier for pet-parents, Zoetis has launched a new product called Simaprica Trio that almost covers all the parasites that haunt your dog. But, its efficiency cannot be measured without comparing the product with existing popular and trusted products.

Therefore, to give a clear picture of Simaprica Trio for dogs, here’s it has been compared with all-time-trusted Heartgard Plus for dogs. Let’s get into the details.

Simparica Trio for Dogs

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Simparica Trio is the upgraded form of the renowned Simparica chewable oral treatment. The Zoetis manufactured product is powerful and potent chewable that works as a multi-spectrum treatment to protect dogs from heavy flea and tick infestations. Moreover, Simparica Trio aids in the thorough control of roundworms and adult hookworms. The chews are indicated for the prevention of heartworm.


Heartgard Plus for Dogs

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Heartgard Plus for dogs is a vet recommended heartworm preventive. A popular monthly treatment effectively controls heartworm infection and provides total protection against heartworm disease in dogs. The palatable chews also eliminate hookworm and roundworm from the dog’s system.  It safeguards dogs from harmful heartworm disease and intestinal worms.


Simparica Trio v/s Heartgard Plus



Simaparica Trio

Heartgard Plus

Active Ingredients

Sarolaner, Moxidectin, and Pyrantel Pamoate


Ivermectin and Pyrantel Pamoate

How does it work?

Sarolaner helps in the thorough elimination of fleas and ticks whereas Moxidection aids in the prevention of heartworm disease. On the other hand, Pyrantel helps in treating and controlling roundworms and hookworms.


Ivermectin is effective in treating the immature form of heartworms. It controls the onset of heartworm disease. The other ingredient pyrantel treats and prevents intestinal worms including roundworms and hookworms in dogs. The two ingredients kill parasites through spastic muscle paralysis and protect dogs from parasitic danger.

Kills fleas:



Kills flea before they lay eggs:



Kills ticks:

Yes, it kills five types of ticks including gulf coast ticks, American dog ticks, Lone star ticks, deer ticks, and Brown dog ticks


Treats intestinal worms:

It effectively treats and controls intestinal worms like roundworms and hookworms in dogs.

Heartgard Plus effectively eliminates roundworms and hookworms in dogs.

Prevents heartworms:

Simaprica Trio is indicated for the prevention of heartworms in dogs.

It assists in killing heartworm larvae which get transmitted to your dog by annoying bloodsuckers thus helping to prevent heartworm disease.


Simaprica Trio is palatable liver-flavored chew.

Heartgard Plus is a beef-flavored chewable.




Safe for pregnant dogs:

The safe use of Simparica Trio has not been evaluated in breeding, lactating, or pregnant dogs. It is suitable to use for puppies and dogs over the age of 8 weeks old or older.

Yes. When used as directed, Heartgard Plus has a wide safety margin in all breeds of dogs, including stud dogs, breeding bitches and puppies 6 weeks or older.

Mode of administration





Merial/Boehringer Ingelheim


A short video that will help you to understand the difference between Heartgard Plus and Simparica quickly!



Simparica Trio and Heartgard Plus are two powerful products in the pet market that holds a similarity in treating intestinal worms and preventing heartworms in dogs. However, it is essential for pet parents to know that Simaprica Trio is the first monthly chewable to protect dogs against five types of ticks, fleas, roundworms, hookworms and heartworms, which makes it an all-in-one monthly treatment. Where Heartgard Plus can only be used to treat woodworm, hookworm and to prevent heartworms. Therefore, if you are looking for a one-stop-solution to combat all parasites then Simparica Trio is the right pick.

So, what are you waiting for? Both the potent products are available at CanadaVetExpress at discounted prices.