How Effective Is Afoxolaner against Fleas and Ticks?

Nexgard-Afoxolaner-in-dogsWe often receive queries about ingredients in the products we sell. It’s a known fact that fleas and ticks are unavoidable without preventives. Sometimes, people get confused when numerous products are available for treating parasites. Dog owners just want to keep those pestering parasites away from their pets. We wish the same for your furry pal. Therefore, we have answered some frequently asked questions regarding Afoxolaner.

So, let’s start with the commonly asked questions about the effectiveness of Afoxolaner. (Don’t miss out the last part of this article! It contains an excerpt of the field study on flea-infested dogs.)


What Is Afoxolaner?

Every pet parent wants a full-proof formula to treat fleas and ticks. Our answer is always the same – Afoxolaner (Brand name Nexgard). Afoxolaner is administered to control and treat flea and tick infestation. It goes into the bloodstream of the dog within 8 hours of administration. Later on, when the flea or tick bites on the dog for its blood meal, it is exposed to Afoxolaner. As a result, all the fleas and ticks are destroyed.



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How to Administer Afoxolaner to My Dog?

It comes in a flavored chewable form for easy administration to dogs. It can be given before or after the meal. If your pooch spits out or throws out the tablet after administration, another dose should be given. Next time, consider mixing it with his meal so he doesn’t repeat the same thing.


How Does It Work?

The active ingredient Afoxolaner halts the neuro-transmission of fleas and ticks by over-stimulating their nervous system. This process eradicates those pesky critters from your dog’s body.

Is It Safe?

Afoxolaner is safe to administer as long as your dog doesn’t have any other disease or allergic to the ingredient. If your dog is suffering from another disease, consult your vet before starting this treatment. It should be administered according to the instructions given on the package.


Effectiveness Of The Product

Many dog owners love this product because of its fast-acting properties. With Afoxolaner, you can forget about fleas and ticks on your dog!

It treats & kills –

  • Adult fleas in 12 hours of administration
  • Ticks within 48 hours of administration

Furthermore, it kills adult fleas before they lay eggs, hence stops the flea infestation altogether.


Are There Any Side Effects?

There have been very few cases where dogs have to face repercussions because of Afoxolaner. However, if your dog has any history of seizures, you need to consult your vet first.

If your dog suffers from any of the following side effects, take him to a vet clinic immediately – vomiting, loss of appetite, lethargic, dry or flaky skin, diarrhea, etc.

Note: The product has not been evaluated on pregnant, breeding or lactating female dogs. In addition to that, don’t use this product on dogs having a history of seizures, muscle tremors, and ataxia.


You may also like to read – Nexgard Guidelines For Novice Dog Parents


Field Study: Evaluation of Afoxolaner And Fluralaner

This information is about a field study conducted on flea and tick infested dogs. Its main purpose was to evaluate the effectiveness of Afoxolaner and Fluralaner. Both of them are flea and tick treatments.

The study took place in Florida where it compared the above two products and evaluated their efficacy. For this purpose, we are only focusing on the results of Afoxolaner on infested dogs. If you wish to read the entire article, you can find the link at the end of this blog.



  • The study was conducted on 27 dogs living from 17 different homes. It was a 3-month study where all the dogs were naturally infested by fleas and ticks.
  • The products were administered according to the instructions on the label.
  • After administration, all the dogs were assessed in that period to evaluate the flea population.
  • During that study, no other treatments were allowed.



  • Upon administration of Afoxolaner, flea population reduced by 99.3% within the first week.
  • After 3 months of regular administration, 100% flea population was eliminated.
  • The households also showed a considerable amount of reduction in the flea population.

This reflects how powerful Afoxolaner is in treating flea and tick infestation. We hope that whatever queries you had were cleared in this article.

Field study reference –