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Brand: Comfortis Plus (Trifexis) Chewable Tablets
Uses: Prevents heavy flea infestation and controls heartworm infections.
Doses: 1 Chew = 1 Month

Comfortis Plus (Trifexis) Chewable Tablets

4.7/5 (138 Reviews)
In Stock, Price Starting From: $76.11

Comfortis Plus (Trifexis) Chewable Tablets For Very Small Dogs 2.3-4.5 Kg (5 - 10lbs) Pink

Pack Size
Sale Price
6 Chews
12 Chews

Comfortis Plus (Trifexis) Chewable Tablets For Small Dogs 4.6-9 Kg (10.1 - 20lbs) Orange

Pack Size
Sale Price
6 Chews
12 Chews

Comfortis Plus (Trifexis) Chewable Tablets For Medium Dogs 9.1-18 Kg (20.1 - 40lbs) Green

Pack Size
Sale Price
6 Chews
12 Chews

Comfortis Plus (Trifexis) Chewable Tablets For Large Dogs 18.1-27 Kg (40.1 - 60 lbs) Blue

Pack Size
Sale Price
6 Chews
12 Chews
  • Description
  • Key Benefits
  • Directions
  • Safety
  • More Info

Comfortis Plus for Dogs

Comfortis Plus is a monthly chewable tablet effective in controlling fleas, intestinal worms and heartworms. It kills fleas rapidly and protects against flea infestation for one-month long. Preventing flea reinfestation, Comfortis Plus is useful to control flea allergy dermatitis. When given regularly every month, the oral treatment provides protection against heartworm disease. It treats intestinal worms including roundworms, hookworms and whipworms. Comfortis Plus is safe to use in dogs and puppies 8 weeks of age.  

How does it work?

Comfortis Plus contains spinosad and milbemycin oxime as the active ingredients. It kills fleas by altering the nerve cell functions and then, thoroughly eliminates. Spinosad is effective in killing existing adult fleas and the other ingredient milbmycin oxime eliminates immature heartworm larvae and intestinal worms. The combination works effectively without triggering the health of a dog. The effectiveness does not reduce by swimming or bathing.

Key Benefits
  • Effective heartworm and flea preventive
  • Kills fleas rapidly and controls flea infestation for one month
  • Prevents heartworm disease
  • Controls intestinal worm infection
  • Easy to administer tasty tablet with no chemical residue
  • No spot-on mess
  • Can be used with other flea and tick treatments
  • Safe for puppies 8 weeks of age
  • Select the pack according to your dog’s weight.
  • Give it orally by mixing it with food.
  • Ensure the whole dosage is taken.
  • Store it in a cool and dry place.
  • Do not administer to pregnant or nursing dogs.
  • Keep out of reach of children and pets.
  • Do not give to dogs allergic to the active ingredients present in the product.
  • It is recommended to have Heartworm test for your dog before starting the treatment.
More Info
Target species Dogs
Mode of Administration Oral
Ingredients Spinosad, Milbemycin Oxime
Brand Name Comfortis
Customer Review

Overall Rating


138 reviews

Sort By:

Suzanne Belhumeur

Great stuff

I love the Products that I have ordered and I receive them in a timely manner. My only complaint is that I never get a tracking number. It would just be nice . Thank you

Jun 10, 2024


Works well

A wide-ranging recipe for my dog.

May 29, 2024



What a fantastic product! It is affordable, simple to use, and performs as promised.

May 18, 2024

Latafath Hussain


Great professionals to work with.

May 15, 2024

Lara Applegate

Simple. Effective


May 09, 2024

Have A Question?

question-arrow Do you carry the comfortis for xlarge dogs (60 - 120 lbs) ?

next-arrow The largest size we carry for Comfortis Plus is Comfortis Plus (Trifexis) Chewable Tablets For Large Dogs 18.1-27 Kg (40.1 - 60 lbs) Blue. For dogs larger than 60 lbs, you may use a combination of Comfortis Plus chews after consulting with your vet.

Jun 10, 2024
question-arrow Can I buy the tablets for my 60 lb dog and then cut the tablets in half for my 20 lb dog?

next-arrow We recommend you consult with a veterinarian about this.

Jul 28, 2023
question-arrow Is this effective against deer ticks?

next-arrow Comfortis PLUS provides 3-in-1 parasite protection for your dog, with protection against fleas, heartworm, and intestinal worms (excluding tapeworm).

Jun 16, 2022
question-arrow can this be given to cats?

next-arrow No

May 03, 2022