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Simparica TRIO
Simparica TRIO
Simparica TRIO
Simparica TRIO
Simparica TRIO
Simparica TRIO

Simparica TRIO for Dogs 44.1-88 lbs (Green)


Select Pet's Size

  • 2.8-5.5lbs
  • 5.6-11lbs
  • 11.1-22lbs
  • 22.1-44lbs
  • 44.1-88lbs
  • 88.1-132lbs

Select Pack

  • 3 DOSES
  • 6 DOSES
  • 12 DOSES
Simparica TRIO for Dogs 44.1-88 lbs (Green) 3 DOSES

Delivery Frequency

Uses: Eliminate fleas and various types of ticks effectively. Also, prevents heartworm in dogs.

Doses: 1 Chew = 1 Month

  • Description
  • Key Benefits
  • Directions
  • Safety
  • More Info
  • FAQ

Simparica Trio for Dogs 44.1-88 lbs (Green)

Simparica Trio (Green) is a monthly liver-flavored chewable tablet that offers triple action protection for dogs weighing 44.1 to 88lbs with the green pack. It is designed to protect large dogs against fleas, ticks, heartworm disease, and intestinal parasites, providing comprehensive coverage in a single dose. The combination of three active ingredients; sarolaner, moxidectin and pyrantel work together to provide fast-acting and long-lasting protection. Sarolaner, the first active ingredient, kills fleas and ticks within hours of administration. Moxidectin and pyrantel, the second and third active ingredient, target gastrointestinal worms such as roundworms and hookworms and also protect against heartworm disease.

This easy-to-administer chewable tablet come in a 3, 6, and 12 doses pack sizes specifically designed for dogs weighing 44.1 to 88lbs, making it convenient for pet parents to provide their pets with the necessary protection and care they deserve.

How does it work?

Sarolaner, Moxidectin, and Pyrantel are the three active components that make up Simparica Trio. The first component, Sarolaner, aids in the flea and tick eradication process while moxidectin and pyrantel prevent heartworm disease and treats and controls roundworms and hookworms in dogs starting at the age of 8 weeks and weighing 2.8 pounds of body weight.

Key Benefits
  • Multi-parasitic internal and external parasite treatment.
  • Tasty liver-flavored chewable tablet for dogs.
  • Packed three proven ingredients for parasite protection.
  • Protects dogs against heartworm disease for one month.
  • Eliminates fleas, ticks, roundworms and hookworms.
  • Provide protection against Lyme disease infection.
  • Suitable for dogs and puppies from 8 weeks of age.
  • Choose the pack as per your dog’s weight.
  • Administer the chewable tablet as per the recommended dose.
  • Chewable can be offered to the dog with or without food.
  • Give the tablet to your dog in such a way that it stimulates chewing rather than ingesting it without chewing.
  • Ensure your dog consume the complete dose for full efficacy.
  • Repeat the treatment every month for best results.
  • For more details, refer to the product label.
Follow the below given table for appropriate dosing and pack size
Dog Size Dog Weight Pack Color Dosage Strength
Puppy 2.8-5.5 lbs Gold One tablet per month 3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg Pyrantel
Extra Small Dogs 5.6-11 lbs Purple One tablet per month 6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg Pyrantel
Small Dogs 11.1-22 lbs Caramel One tablet per month 12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg Pyrantel
Medium Dogs 22.1-44 lbs Teal One tablet per month 24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg Pyrantel
Large Dogs 44.1-88 lbs Green One tablet per month 48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg Pyrantel
Extra Large Dogs 88.1-132 lbs Brown One tablet per month 72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg Pyrantel
For Dogs weighing more than 132lbs use an appropriate combination of tablets
  • For animal use only
  • Store in a cool and dry place
  • Do not use in breeding, pregnant, or lactating dogs
  • Wash hands thoroughly after handling the product
  • Keep out of reach of children and other household pets
More Info
Target Species: Dogs
Prevention/Treatment Type: Internal and External Parasite Protection
Product Form: Chewable Tablet
Effective For: Fleas, Ticks, Roundworms, Hookworms, Heartworm and Lyme Disease
Dosing Frequency: Monthly
Mode of Administration: Oral
Active Ingredients: Sarolaner, Moxidectin, Pyrantel

What is Simparica Trio?

Simparica Trio is a broad-spectrum treatment that protects dogs and puppies from various external and internal parasites like fleas, ticks, heartworms, and intestinal worms.

Is Simparica Trio good for dogs?

Simparica Trio is a first-of-its kind chewable treatment that offers triple protection for your dog. Its unique trio of ingredients keeps your dog safe from all major dog parasites, including fleas, ticks, heartworms, and intestinal worms.

How long is Simparica Trio effective?

One chew of Simparica Trio is effective for up to 30 days.

Does Simparica Trio cover gastrointestinal nematodes?

Yes, Simparica Trio works against gastrointestinal nematodes like roundworms and hookworms.

Is Simparica Trio suitable for all dog ages?

Simparica Trio is suitable for dogs and puppies as young as 8 weeks old, weighing at least 2.8 lbs.

What kind of ticks does Simparica Trio cover?

Simparica Trio is approved to kill 5 types of ticks including the Gulf Coast tick, deer tick, America dog tick, Lone star tick, and Brown dog tick.

Does Simparica Trio prevent Lyme disease in dogs?

Simparica Trio blocks tick infections that transmit at least 15 different serious diseases to dogs, including the Lyme disease.

How does Simparica Trio work?

Simparica Trio is formulated with a trio of ingredients uniquely combined for proven efficacy. It contains sarolaner, which provides 35 days of immediate and persistent flea efficacy, moxidectin, which offers proven heartworm defense, and pyrantel, which works against hookworms and roundworms. The single-dose chewable thus protects your dog from the dangerous parasites.

Still Have Questions? – Please email us your queries at and we will be happy to help you.

Customer Review

Overall Rating


284 reviews

Sort By:

David Barto



Jun 03, 2024

Betty Berthold

Simparica trio

Works great

Jun 02, 2024

Terri Mcwaters

5 Stars


Jun 01, 2024


Extremely useful

Completely safe for pups and comes with a satisfaction guarantee of 100%.

May 24, 2024

Kathleen Rozyskie

Highly recommended product

My Vet indicated that he uses this for his dogs. That’s a good enough recommendation for me!

May 21, 2024

Have A Question?

question-arrow does the simparica trio prevent tape worms

next-arrow No, Simparica Trio is not known to protect against tapeworms.

Nov 06, 2023
question-arrow I accidently ordered the wrong dosage size of Simperica Trio. What are my options? Thank you.

next-arrow Please contact our customer support help desk at 1-800-279-7001.

Oct 23, 2023
question-arrow How do we know its not a knock-off drug. Pretty inexpensive.

next-arrow We only sell genuine and authentic products. You can check the ingredients and the manufacturer of the product to ensure that it is the same product you get from your vet or store near you.

Sep 15, 2023
question-arrow Do you have Simparica trio for cats?

next-arrow No, Simparica Trio is only to be used on dogs. There's no Simparica Trio for cats available.

Sep 04, 2023
question-arrow I am looking at this on Canada Vet Express, I’m confused why is it delivered free shipping from USA? Is this in US dollars or Canadian dollars?

next-arrow Yes, we provide free shipping on all orders and all the product prices are mentioned in US dollars.

Aug 14, 2023
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